Relationship between Human Herpes Virus Type 6 and Childhood T-Cell Leukemia-Lymphoma

Background: Previous studies have pointed to the major role of viruses in pathogenesis cancers, especially lymphoproliferative cancers. Objectives: The current study investigated relationship between recent Human Herpesvirus Type 6 (HHV6) infection and childhood leukemia-lymphoma syndrome. Methods: From January 2011 December 2012, we entered every new case acute lymphoblastic leukemia, non-Hodgkin lymphoma, myeloblastic Hodgkin lymphoma as group (n=48); moreover, 60 patients were randomly selected controls from hospitalized children without infectious agents myocarditis department pediatric cardiology Shiraz, Iran. Immunophenotyping bone marrow or lymph node biopsy was performed for group. DNA extracted all collected samples using a extraction kit (Invitek Company, Germany), Real-time quantitative polymerase chain reaction (qPCR) U38 gene HHV-6 detection genome both groups. Results: In group, 48 with age range 0-18 years assigned four subgroups: 1- Acute Lymphoblastic Leukemia, 2- Myeloblastic 3- Lymphoma, 4- Lymphoma. there positive PCR patients: One one Non-Hodgkin two Lymphoma subgroup. None T-cell had PCR. frequency HHV6 not significantly different (8.3%) control (1.6%) groups (P=0.169). No detected leukemia/lymphoma patients. Conclusion: As evidenced by results present study, has no significant difference T-Cell healthy people.